Jarrow Formulas® SAMe 400 yields 400 mg of active SAMe from 800 mg of SAMe tosylate disulfate, crafted with meticulous precision for optimal potency. It's carefully prepared under low temperature and low humidity then enteric-coated for lasting effect.
Contains More of the Active S,S Form

Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas® SAMe is made naturally by microbiological fermentation and then specially processed without chemical solvents to preserve 68-80% (S,S) SAMe, the highest active level available.

SAMe has been clinically shown to have the following benefits:

Joint Strength

SAMe aids the creation of robust connective tissue via transulfuration.* This process enables components of connective tissue, called glycosaminoglycans (GAGs), like glucosamine and chondroitin, to generate sulfated GAGs such as glucosamine sulfate and chondroitin sulfate.*
Brain Metabolism

SAMe methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).*

Liver

SAMe metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase, glutathione reductase and glutathione-S-transferase), which are components of the body’s endogenous antioxidant network and important for liver function, including phase II detoxification.*

Jarrow Formulas® SAMe 400 is foil blister-packed to maximize stability and safety. DO NOT use if outer seal of blister pack is broken.

Full Potency 400 mg SAMe (net yield) is derived from 800 mg of SAMe tosylate disulfate.

For best results, use with Jarrow Formulas® JarroSil®, the biologically Activated Silicon®.