Hips, Shoulders, Knees and Toes is a professional strength blend of proteolytic (protein digesting) enzymes including Serrapeptase, and herbs. Unlike glucosamine, Serrapeptase appears to work by helping break down cellular debris in the body. This debris may inhibit blood circulation to joint areas. Enhanced blood flow may allow nutrients to reach the joints, encouraging cellular activity. Similar formulations have demonstrated clinical mobility benefit in as little as 15 days.